A Study Patients who received a transplant of Fécal Microbiota (FMT) for Difficult clostridioides Information (RCDI) in six American hospitals identifies the largest risk factors for subsequent use of antibiotic, went to last week at the end of last week Open infectious diseases.
The study, led by researchers from the University of Minnesota, was a secondary analysis of a prospective cohort study of patients who received FMT for the RCDI from July 2019 to November 23, 2023.
The FMT implies the transfer of stools of health donors to help restore the intestinal microbiome of pations with RCDI, which occurs in around 20% of CDI pations infection and becomes more risk with each following episode. Although the FMT has proven to be effective as a RCDI AR treatment and is approved by several medical companies to manage RCDI, researchers wanted to study non-CDIs exposure to antibiotics in patients with 2 months of FMT, because this number disrupts the restoration of the intestinal microbiome and control of control.
Analysis tilted 448 patients from the Origel study. Among these patients, 82 (19%) were originally, 147 (34%) were hospitalized for CDI and 49 (11%) were exposed to non -CDI antibiotics with 2 months of FMT. The most commonly reported renes for non -CDI antibiotic administration were urinary tract infections, respiratory track infections and procedural prophylaxis.
A “potentially modifiable” risk factor
Risk factors of non-CDI antibiotics with 2 months of immunocococromized status included FMT (Ratio of Cotes [OR]2.2; 95% confident interval [CI]1.1 to 4.4), more than three non-CDI pre-fm (gold, 3.1; 95%CI antibiitic courses, 1.4 to 6.8), and anterior hospitalization for CDI (gold, 2.0; 95%CI, 1.1 to 3.8).
The study authors say that the results are high
“Unlike antibiotics on the CDI after the FMT is a potentially modifiable risk factor,” wrote the authors of the study. “The evaluation of these risk factors as well as the underestimate of the initial trigger for CDI can help develop a complete planet to prepare for subsequent CDI episodes.”
